Over time and especially in the 20th century, chronic obstructive pulmonary disease (COPD) will become a major cause of morbidity and mortality. Extrapulmonary comorbidities are more prevalent in patients with COPD than the general population and seriously increase the exacerbations, hospitalizations and mortality associated with the COPD. In general, the pathophysiological mechanisms between the comorbidities and COPD are unclear. However, in particular comorbidities related with endocrine disorders in the COPD are frequently under-diagnosed and under-treated. In this section, we focus on and detail the endocrine comorbidities in COPD patients in point of their prevalence, prognosis, diagnosis, pathophysiological mechanisms and management approaches.