Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous respiratory disorder that carries a significant morbidity and mortality on individuals. Comorbidities, defined as other chronic medical conditions, are common in patients with COPD. The disease rarely occurs in isolation, but often is a part of more complex multisystem syndrome with a large number of associated comorbidities. Recent epidemiological studies suggest that COPD is associated with some age driven diseases, such as hypertension, cardiovascular diseases, diabetes, osteoporosis, asthma, lung cancer, sleep apnea, and mental disorders. The comorbidities can be clustered into identifiable groups based on pathophysiological determinants that could be to create better phenotypes of patient with COPD.